Sofyan Amrabat will once again play in the unfamiliar left-back role in the absence of Sergio Reguilon, Luke Shaw and Tyrell Malacia.
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Hannibal Mejbri, Donny van de Beek, Alejandro Garnacho and Anthony Martial are the other substitutes. This means that Antony, who rejoined training today after having been given leave to resolve a police matter, was not deemed fit enough even for the bench.
The United bench includes both Scott McTominay and Christian Eriksen, who return to the squad after being ill in midweek.
Kick off at Old Trafford is at 3pm.
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Mount is joined by Casemiro in midfield, with Bruno Fernandes ahead of them.
It is the trio that started the season that struggled to control possession against Wolves and Spurs.
Lisandro Martinez and Aaron Wan-Bissaka are also injured.
The centre back pairing will be Raphael Varane and Victor Lindelof.
Mason Mount and Facundo Pellistri are both starting for Manchester United against Crystal Palace this afternoon.
Jadon Sancho is still banished from the team pending an apology to the manager.
Andre Onana is in goal and Diogo Dalot at right back.
Jonny Evans and Harry Maguire are the defensive backups.
Marcus Rashford and Rasmus Hojlund return at left wing and centre forward, respectively.
Altay Bayindir is the reserve keeper.
Kobbie Mainoo and Amad Diallo are nearing fitness but not yet available.